|Systematic (IUPAC) name|
|Trade names||Uloric, Adenuric, Atenurix|
|Licence data||EMA: , US FDA:|
|Protein binding||~99% to albumin|
|Metabolism||via CYP1A2, 2C8, 2C9,UGT1A1, 1A3, 1A9, 2B7|
|Excretion||Urine (~49% mostly as metabolites, 3% as unchanged drug); feces (~45% mostly as metabolites, 12% as unchanged drug)|
|Mol. mass||316.374 g/mol|
SEE,,,,,,,,http://www.allfordrugs.com/2016/07/10/febuxostat/Ni-based catalytic systems for the arylation of heteroarenes with aryl halides and triflates have been established. Ni(OAc)2/bipy is a general catalyst for aryl bromides/iodides, and Ni(OAc)2/dppf is effective for aryl chlorides/triflates. Thiazole, benzothiazole, oxazole, benzoxazole, and benzimidazole are applicable as heteroarene coupling partners. A rapid synthesis of febuxostat, a drug for gout and hyperuricemia, is also demonstrated.