All about Patents and Intellectual property by DR ANTHONY MELVIN CRASTO, worlddrugtracker, Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry, Serving chemists around the world. THE VIEWS EXPRESSED ARE MY PERSONAL AND IN NO-WAY SUGGEST THE VIEWS OF THE PROFESSIONAL BODY OR THE COMPANY THAT I REPRESENT, firstname.lastname@example.org, +91 9323115463 India
A solution of 1,1-dimethylethyl
3-pyrrolidinyl]amino}carbonyl)-l-pyrrolidinecarboxylate (72 mg, 0.150
mmol) in HCl (4 M solution in 1,4-dioxane, 0.50 mL, 2.00 mmol) was
stirred at RT for 1 h 25 min. The reaction mixture was diluted with Et2O (2 mL), and the resultant precipitate was filtered through a plug of cotton and washed with Et2O (1 mL). The solid was dissolved in MeOH and concentrated under a stream of nitrogen at 50 0C. Water (2 mL) was added and the mixture was lyophilized with a Genevac® HT-4X to afford the title compound (48 mg, 77%). LC-MS m/z 379 (M+H)+, 0.95 min (ret time).